Changes that impact the framework of chromosomes can cause problems through growth, development, and duty of the body\"s systems. These changes can affect many gene along the chromosome and also disrupt the protein made indigenous those genes.

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Structural changes can occur throughout the formation of egg or sperm cells, in beforehand fetal development, or in any type of cell ~ birth. Pieces of DNA can be rearranged within one chromosome or transferred between two or much more chromosomes. The results of structural alters depend on their size and location, even if it is gene duty is interrupted, and also whether any type of genetic material is obtained or lost. Part changes reason health problems, while others may have no result on a person\"s health.

Changes in chromosome structure include the following:

Translocations

A translocation occurs when a piece of one chromosome breaks off and also attaches to an additional chromosome. This form of rearrangement is described as well balanced if no hereditary material is got or lost in the cell. If there is a obtain or ns of genetic material, the translocation is explained as unbalanced.

Deletions

Deletions occur when a chromosome breaks and also some hereditary material is lost. Deletions deserve to be huge or small, and can occur almost everywhere along a chromosome.

Duplications

Duplications occur when part of a chromosome is abnormally duplicated (duplicated). This kind of chromosomal readjust results in extra duplicates of genetic material native the duplicated segment.

Inversions

An turning back occurs as soon as a chromosome breaks in 2 places; the resulting piece of DNA is reversed and re-inserted into the chromosome. Hereditary material might or may not be lost as a an outcome of the chromosome breaks. An inversion that consists of the chromosome\"s constriction suggest (centromere) is dubbed a pericentric inversion. One inversion the occurs in the lengthy (q) eight or quick (p) arm and does not involve the centromere is referred to as a paracentric inversion.

Isochromosomes

An isochromosome is a chromosome v two the same arms. Rather of one q arm and one p arm, an isochromosome has two q arms or 2 p arms. As a result, this abnormal chromosomes have actually an extra copy of part genes and also are lacking duplicates of genes on the lacking arm.

Dicentric chromosomes

Unlike regular chromosomes, which have actually one centromere, a dicentric chromosome includes two centromeres. Dicentric chromosomes result from the abnormal combination of two chromosome pieces, each of which consists of a centromere. This structures room unstable and often show off a ns of some genetic material.

Ring chromosomes

Ring chromosomes usually take place when a chromosome breaks in two places, commonly at the end of the p and q arms, and also then the eight fuse together to type a circular structure. The ring may or may not encompass the centromere, relying on where ~ above the chromosome the breaks occur. In many cases, hereditary material close to the ends of the chromosome is lost.

Many cancer cells additionally have transforms in their chromosome structure. These transforms are no inherited; they take place in somatic cells (cells other than eggs or sperm) throughout the formation or progression of a cancerous tumor.


The National person Genome study Institute provides a perform of questions and also answers around chromosome abnormalities, including a glossary of connected terms.

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Chromosome Disorder Outreach offers a reality sheet on this topic titled arrival to Chromosomes. This resource includes shown explanations of several chromosome abnormalities.

The Centre because that Genetics education and learning provides a truth sheet about chromosome changes.

EuroGentest offers truth sheets around chromosome changes and chromosome translocations.

The university of Leicester\"s Virtual genetics Education center provides an explanation of structure chromosome aberrations.

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Your Genome from the Wellcome Genome Campus discusses chromosome disorders, including varieties of structure abnormalities in chromosomes that are involved in genetic diseases.