For each of the sites specified in the followingmolecules, indicate whether the site is nucleophilic,electrophilic, or neither by dragging the appropriate label to thebox pointing to the site.

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For each of the sites specified in the following molecules, indicate whether the site is nucleophilic, electrophilic, or neither by dragging the appropriate label to the box pointing to the site.

The structure of various compound marked with different sites is given and these sites needs to be classified as electrophilic, nucleophilic and neutral. Firstly, identify the sites as electron rich and electron poor then, mark the electron rich site as nucleophilic and electron poor sites as electrophilic. The site which is neither rich in electron density nor poor in electron density should be marked as neutral.


Electrophilic sites are generally poor in electron density that is either they are positively charged or attached with the electronegative atom or groups that withdraws their electron density. Electrophilic means they the atom or compounds which have affinity for electrons. For instance, consider the following compound:

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Nucleophilic sites are generally rich in electron density that is either they are negatively charged or attached with the electron donating groups that increases the electron density on the site. Atoms which contain lone pair also act as electron rich site. Nucleophilic means they the atom or compounds which have affinity for protons or positive charge. For instance, consider the following compound:

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Neutral sites are neither attached with electron donating or electron withdrawing groups nor they contain positive or negative charge. Therefore, they are neither electrophilic nor nucleophilic. For instance, consider the following compound:

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Write the structures of the compounds in which the sites are electron poor and a small positive charge is generated on them as shown below:

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Write the structures of the compounds in which the sites are electron rich and a small negative charge is generated on them as shown below:

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Write the structure of the compound having neutral site, that is, neither electrophilic nor nucleophilic as shown below:

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Ans:

Thus, the electrophile and nucleophile sites are shown below:

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