MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.
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Keep the medication in a place where others cannot get to it.
Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
What is ibuprofen and oxycodone?
Oxycodone is an opioid pain medication, sometimes called a narcotic. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). This combination medicine is used short-term to relieve severe pain. This medication is not for treating arthritis pain.
Ibuprofen and oxycodone may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking ibuprofen and oxycodone?
Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don”t have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.
You should not use this medicine if you are allergic to oxycodone or ibuprofen (Advil, Motrin), or if you have:
severe asthma or breathing problems; or a stomach or bowel obstruction (including paralytic ileus).
Tell your doctor if you have ever had:
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke; a heart attack, stroke, or blood clot; a stomach ulcer or stomach bleeding; breathing problems, sleep apnea; liver or kidney disease; a head injury, brain tumor, or seizures; a thyroid or adrenal gland disorder; urination problems; or alcoholism, drug addiction, mental illness.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson”s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with hydrocodone and cause a serious condition called serotonin syndrome.
Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
How should I take ibuprofen and oxycodone?
Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Use the lowest dose that is effective in treating your condition. Tell your doctor if you feel an increased urge to take more of this medicine.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
What happens if I miss a dose?
Since this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include black or bloody stools, coughing up blood, confusion, weakness, cold and clammy skin, very slow breathing, or coma.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to ibuprofen (such as aspirin, ketoprofen, or naproxen).
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg, swelling, feeling short of breath.
weak or shallow breathing, sighing, slow heartbeats, breathing that stops during sleep; swelling or rapid weight gain; a skin rash, no matter how mild; pale skin, feeling light-headed; signs of stomach bleeding –bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; kidney problems –little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or liver problems –loss of appetite, diarrhea, upper stomach pain, tiredness, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes).
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
dizziness, drowsiness; blurred vision; or nausea, vomiting, upset stomach, constipation, diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect ibuprofen and oxycodone?
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (“water pill”); medicines for motion sickness, irritable bowel syndrome, or overactive bladder; other narcotic medications –opioid pain medicine or prescription cough medicine; a sedative like Valium –diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and others; drugs that make you sleepy or slow your breathing –a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or drugs that affect serotonin levels in your body –a stimulant, or medicine for depression, Parkinson”s disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may affect ibuprofen and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Where can I get more information?
Your pharmacist can provide more information about ibuprofen and oxycodone.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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